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    Cocaine is a highly addictive stimulant drug. For thousands of years, people in South America have chewed and swallowed coca leaves (Erythroxylone coca), the source of cocaine, for their stimulant effects.1,2 The purified chemical, cocaine hydrochloride, was isolated from the plant more than 100 years ago. In the early 1900s, purified cocaine was the main active ingredient in many tonics and elixirs designed to treat a wide variety of diseases, and was even an ingredient in the early formulations of Coca-Cola®. Before the development of synthetic local anesthetics, surgeons used cocaine to block pain.1 However, research has since shown that cocaine is a highly addictive substance that can alter brain structure and function with repeated use.